The manuscript sets out a list of principal diseases in alphabetical order giving an overview of the disease and its symptoms. The heading of each disease is in red ink with the rest of the entry following in black. Folios 68-108 are blank.
The headings and subheadings are as follows: abdominis (a flatu in intestinis incarcerato, a viscerum infarctu chronico, a vermibus); abortus signa (a plethora); abscessus signa (externi, interni, post casum vel ictum, in pectore, in hepate); achores sive crustae lacteal [impetigo]; albugines, maculae, labiculae; amaurosis [blindness]; ankyloses; anasarca [oedema]; aneurysma [aneurysm]; angina (catarrhalis, inflammatoria, gangrenosa sive maligna, gangrenosa ab inflammatorio hic modo distinquitur, angina convulsive); anthrax sive carbunculus [carbuncle]; aphtha; apoplexia [stroke], andura, arthritis sive podagral; ascarides [ascaridia]; ascites; asthma; atrophia [atrophy]; bronchocele; bubo; cachexia; calculus renum [kidney calculi]; calculus vesicae [urinary bladder calucli]; calculus vesicae felleae [gallbladder]; cancer (exalceratus sive ulcus cancrosum); cancer mammae [breast cancer, breast neoplasms] (occultus, exulcerationem minantur); cancer uteri [uterine cancer, uterine neoplasms]; carbunculus; cardialgia [heartburn]; catalepsis [catalepsy]; cataracta; catarrhus; catarrhus vesicae; cephalagia [headache]; cerebri commotio [concussion]; chlorosis; cholera morbus; chorea sancti viti [St Vitus's Dance]; colica (biliosa, flatulenta, spasmodica, saturnina [lead poisoning], phlogistica et plethorica, verminosa); coma; convulsio; cordis palpitatio [cardiac arrhythmias]; cordis inflammatio; coryza [common cold]; crampus; cucurbitini vermes; deglutitio lesa sive dysphagia; dentitio; diabetes; diarrhoea; dysenteria; dyspnoea seu anhelatio; dysuria; elephantiasis; emphysema; empyema; epilepsia; epilepsia sive convulsio infantum sive eclampsia; epiphora; erysipelas; epinyetis; essera sive purpura urtucata; essera infantium; febris continuae (ephemera, synocha, synochus, typhus, hectia); febres remittentes [remittent fever] (amphemerina, triteophia, tetartophia); febres intermittentes [intermittent fever] (quotidiana, tertiana, quartana, erratica); fluor albus sive leucorrhoea [leukorrhoea]; fluxus coeliacus [coeliac flux]; fluxus hepatiens; gastrodynia; gutta rosacea; haemoptysis (accidentalis, habituales, a diapedesi, catamenialis, variolosa); haemorrhagia nasium [epistaxis]; haemorrhagia penis; haemorrhoides [haemorrhoids]; hemicrania [headache]; hemiplegia; hepatalgia; hepatitis; herpes; hydrocephalus; hydrophobia [rabies]; hydrops pectoris [hydrothorax]; hydrops pericardii [pericardial effusion]; hydrops ovarii; hydrops uteri; hypochondriasis; hysteralgia; hysteritis; hysteris sive hysteria; icterus [jaundice]; ileus; impetigo; incubus; ischias [sciatica]; ischuria [urinary retention]; lepra; lethargus [lethargy]; lipothymia [syncope]; lippitudo [blepharitis]; lumbago; mentales morbi [mental disorders] (delirium, paraphrosyne, amentia, mania, demonia, vesania, melancholia, insania); meteorismus; mictus cruentus [haematuria]; morbilli; ophthalmia; oedema; paralysis; pemphigus; phrenitis [delirium]; paraphrenitis; pleuritis [pleurisy]; phthisis [pulmonary tuberculosis]; physconia [abdominal swelling]; rachitis [rickets]; rheumatismus [rheumatism]; scabies; scirrhus; scorbutus [scurvy]; scrofula; spasmus; splenalgia; stranguria; syncope; tabes; tenesmus; tetanus; tinea; tussis [cough] (catarrhalis, stomachalis, gutturalis, adentitione, gravidarma, haemoptoica, phthisica); tussis rheumatica; tussis verminosa; tympanites; variolae; vertigo; ventriculi ardor; ventriculi inflammatio; vermes [worms]; vesaniae; vomica pulmonum; vomitus; uteri inflammatio; uteri scirrhus; uteri cancer [uterine cancer, uterine neoplasms].
The manuscript bears the bookplate of the Manchester Medical Society which indicates that it was donated to them by Clay in 1861 and was subsequently allocated the reference GO 2066 viz. their 1890 library catalogue.