The volume bears the bookplate of Charles White (1728-1813) as well as his signature on one of the early pages. Additional notes indicate that it was owned by Samuel Crompton (1817-1891) in 1843 and then given by him to Thomas Radford in 1858. The stamps of various libraries then show it to have been donated by Radford to the Radford Library at St Mary's Hospital where it was allocated the reference O 1290 before becoming part of the main Manchester Medical Society Library at the University of Manchester. The manuscript has the original pagination pp.1-364 and an index in the rear.
Clinical lectures differed from traditional classroom based teaching in that students were taught on the hospital wards using real life patients to illustrate some of the most common diseases and ailments and to see how they should be treated. In this case the patients were seen on the wards of the Edinburgh Infirmary. As such, instead of individually numbered lectures, the notes are presented like patient case notes. The index in the rear lists patients by name with their disease alongside the corresponding page number.
The cases/diseases covered are as follows: gravel & rheumatism, epileptic fits from worms, rheumatism, ague, diarrhoea & haemoptoe [haemoptysis], pleurisy, gonorrhoea, fluor albus [leukorrhoea], venereal disease, scurvy, headache, dropsy [oedema] & diarrhoea, sourness on the stomach, vomiting, heartburn etc., irregular ague, hydrocephalus, smallpox & chin cough, catarrh, stone in the bladder [urinary bladder calucli], scorbutic ulcers [scurvy], sore throat & irregular pulse, peripneumony [pneumonia], jaundice, cachexia, dropsy & asthma etc., hemiplegia & smallpox, cough & pain in the head & breast etc., epileptic fits [epilepsy], hysteric symptoms & obstruction of the menses [amenorrhoea], slow fever, hemiplegia & amaurosis [blindness] etc., white swelling, want of menses, scrofula [tuberculosis, lymph node] & haemoptoe, convulsive motion, palsy [paralysis], suppression of the lochia after child bearing, dropsy and after that epileptic fits etc.
On pp.353-364 is a small section entitled 'An abstract of a lecture of Professor Monro's upon a surgical patient in the Edinburgh Infirmary' in which the case of Margaret Watson who has been diagnosed with a burnt breast is discussed.